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Archive for the ‘autoimmune disease’ Category

Feb
07

George Scangos – The 25 most influential people in biopharma today

Posted under autoimmune disease, BG-12, Biogen Idec, Blog, Carl Icahn, Companies, daclizumab, Diagnostics, Funding, George Scangos, Medical Devices, Medical Supply, Pharmaceuticals, Startups, Universities, Videos by Ryan McBride

Setting the pace on prioritization

George Scangos
CEO
Biogen Idec

George Scangos has shown that he belongs in the small fraternity of the very top chief executives in biotech, bringing what appears to be a golden touch to one of the industry's most important companies, Biogen Idec ($BIIB). Biogen, which had lagged biotech peers in R&D productivity and stock price before Scangos' arrival in June 2010, has been returning to grace under his leadership.

The Weston, MA-based company's stock took off last year, fueled by positive data on key experimental therapies such as the multiple sclerosis pill BG-12 and the long-acting MS treatment daclizumab. Those programs predate Scangos' arrival, but he has refocused the company's R&D organization on the areas it knows best such as neurological and autoimmune diseases.

He's been decisive--cutting oncology and cardiovascular disease research from the company's R&D mix and shuttering its San Diego research outpost just months after taking the reins. He made changes and appointments on his executive team, surrounding himself with standout veterans of the biotech game. And he made the call last year to return the company's headquarters to Cambridge, MA--all as part of his larger leadership theme of improving communication and integrating efforts.

Abandon oncology research? It's almost unheard of in biopharma nowadays, but Scangos has set the tone among his peers for prioritization--which has become essential as drugmakers narrow their focus on their most valuable programs to get the best returns possible on their R&D dollars.

Scangos also hasn't hesitated to shrug off some big trends in the business. Early on Scangos' new team decided to get out of the corporate VC side of the business, happy to go their own way and rely on a seasoned team to provide the kind of insights on new companies and technologies expected from the corporate VC teams roaming the planet. He hasn't been emulated, yet.

The hundreds of workers who lost their jobs as a result of Scangos' house-cleaning in the fall of 2010 might disagree, but Scangos has even been regarded as a friendly leader who is liked among the rank and file. (It probably doesn't hurt that employees' company stock has skyrocketed with Scangos in charge.) Yet there's no doubt that Scangos exudes confident calm, something that was seriously lacking during the infamous charades at the '09 annual shareholder meeting, when management and Carl Icahn's camp were battling for as many board seats as each could get.

Scangos' first annual board meeting was perfectly boring, another sign of contentment among investors. How content? Icahn cashed out his shares in Biogen last year. A Scangos-led Biogen had finally delivered the billionaire investor what he wanted, a big profit. With BG-12 advancing, we'll soon see whether Scangos can lead Biogen to a feat it hasn't accomplished since 2004--an FDA approval of a new drug.

Dec
27

Pfizer R&D pact could inject $217M into Karo Bio

Posted under autoimmune disease, Blog, Companies, Diagnostics, Funding, Karo Bio, Medical Devices, Medical Supply, multiple sclerosis, Pfizer, Pharmaceuticals, Startups, Universities, Videos by Ryan McBride

Swedish biotech Karo Bio's ($KARO) shares spiked after the company revealed a new research and development deal focused on autoimmune diseases with U.S. drug giant Pfizer ($PFE). Karo, which has been planning cutbacks and a spin-off, could reap as much as $217 million in upfront and milestone fees, in addition to royalties, from Pfizer, the company announced Dec. 24.

Karo's shares surged 80% after the announcement, the biggest jump since the stock hit the public market in 1998, Bloomberg reported. The upbeat news came amid upheaval at the Huddinge, Sweden-based company, which announced 25 staff cuts Nov. 1, about a week after revealing plans to spin off its preclinical business and reduce expenses.

The Pfizer deal centers on Karo's small molecule RORgamma (RORgt) modulators against autoimmune diseases such as multiple sclerosis, rheumatoid arthritis and psoriasis, according to Karo's release. Pfizer will provide all of the funding for the collaboration and get exclusive worldwide market rights to drugs developed under the agreement. Karo said it's already discovered drugs targeting the nuclear hormone receptor RORgamma, which triggers the production of an inflammation-causing protein called IL-17. The protein is the progeny of T helper 17 cells, or Th17s, which are key players in numerous immune-related diseases.

"The central role of RORgt in Th17 cell differentiation coupled with the increasing clinical validation for the importance of IL-17 and other Th17-derived cytokines in autoimmune diseases, makes RORgt a compelling target," Jose-Carlos Gutierrez-Ramos, Pfizer's senior vice president, biotherapeutics, worldwide R&D, said in a statement. "Combining KaroBio's deep expertise in nuclear hormone receptors with the world-class chemistry and cytokine immunology expertise of Pfizer has the potential to accelerate our drug discovery effort in this competitive area."

A bevy of drug companies are now involved in research of drugs targeting Th17-related pathways. The big ones include GlaxoSmithKline ($GSK), Biogen Idec ($BIIB) and Merck ($MRK), and startups including GSK-backed Tempero Pharmaceuticals and Merck partner Lycera have been active as well.

- here's the release
- see Bloomberg's article

Related Articles:
Karo Bio prepares to spin off preclinical work, cut costs
Lycera snags $307M anti-inflammatory discovery deal with Merck

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