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Archive for the ‘Dimebon’ Category

Feb
07

Ian Read – The 25 most influential people in biopharma today

Posted under Blog, Companies, Diagnostics, Dimebon, Funding, Ian Read, Lipitor, Medical Devices, Medical Supply, Medivation, Pfizer, Pharmaceuticals, Startups, Universities, Videos by Mark Hollmer

Focused on the bottom line

Ian Read
CEO
Pfizer

New Pfizer ($PFE) CEO Ian Read took the top spot in late 2010 with a mandate to make the sluggish drug giant more nimble, if it ever was.

Read is enormously important to the industry because his initial solution amounted to a sea change--a $1.5 billion reduction in spending on research and development. That, so far, has translated into about 4,220 job cuts announced over the previous year as of Jan. 4, including 1,100 in Connecticut, and most of the 2,400 jobs at Pfizer's Sandwich, U.K., lab, as reported by The Guardian and others. Observers will be tracking those changes closely, wondering if drastically reducing in-house R&D in favor of later-stage drug development can be more successful.

Wall Street analysts loved the greater focus on the bottom line, and now Pfizer's competitors--including Eli Lilly, AstraZeneca and others--now face profound pressures to do the same unless they can improve the performance of their similarly struggling R&D operations.

The other part of the equation: Read swore off large acquisitions in favor of licensing deals and companies with mid-to-late-stage drug candidates, a potentially cost-effective way to outsource development and fill the gaps created by gutting the company's in-house R&D. Partnerships, however, remain a mixed bag for Pfizer. Earlier this year, Pfizer wrote off its $725 million partnership deal with Medivation after that company's Alzheimer's drug Dimebon disappointed in Phase III trials.

Still, the job's not over yet. Read committed to an ongoing review of all of the company's operations, with some big changes. He's streamlined some global management functions and Pfizer announced plans to shed its $3.6 billion animal health business and its $1.9 billion nutritionals business and focus on its late-stage pipeline. But some observers want the company to commit to far more aggressive downsizing and streamlining.

Read, meanwhile, is trying to keep Pfizer in play with generic competition through discounts and co-pay assistance programs, a unique solution also likely to be closely watched by industry.

Jan
17

Pfizer writes off $725M Dimebon pact after final Phase III failure

Posted under Blog, Companies, Diagnostics, Dimebon, Funding, Huntington's, MDV3100, Medical Devices, Medical Supply, Medivation, Pfizer, Pharmaceuticals, Prostate Cancer, Startups, Universities, Videos by John Carroll

The last flickering hope that Medivation's Dimebon could help Alzheimer's disease patients has just been extinguished. The biotech announced this morning that a 12-month study of the drug failed to register significant improvements for patients, mirroring two shorter Phase III studies in which Dimebon failed to outperform a sugar pill. Pfizer ($PFE) took the opportunity to bow out of its partnership, writing off its $225 million upfront and $500 million milestone program for what proved to be another embarrassing pipeline failure.

In 2008, Dimebon looked like an odds-on success, with positive data from a Russian study and 10 years of sales experience to underscore its safety. But Medivation ($MDVN) was shaken to the core when its first late-stage study ended in failure, with an additional pratfall for Huntington's disease to cap the disaster.

In the end, Dimebon's failure helped tarnish the reputation of Russian drug studies while raising severe doubts about Medivation. But the company and CEO David Hung managed to turn attention to MDV3100 for prostate cancer, with positive data reigniting hope in the biotech's future and reviving its battered share price. Pfizer, meanwhile, says it won't give up on Alzheimer's, which is one of the most difficult fields in drug development.

"We recognize Alzheimer's is a very complex disease," said Pfizer's Dr. Steven J. Romano. "Despite this disappointing result, Pfizer remains committed to advancing the science of Alzheimer's disease, with the ultimate goal of delivering innovative and meaningful new treatment options to patients."

Shares of Medivation declined slightly this morning, indicating the market's near-zero expectations for Dimebon.

- here's the press release

Related Articles:
Abiraterone vs. MDV3100: A prostate cancer drug showdown
Medivation's Dimebon fails Phase III for Alzheimer's, shares collapse
Medivation's Dimebon flunks Ph3 for Huntington's disease